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Karnakar B, Arvapalli S, Jabeen S, Vaishnvi A, Rishika PS, Sharma JVC

GPX4 can be modified by ubiquitination on Lys47, Lys80, Lys107, Lys135, Lys162, and Lys167 or by phosphorylation on Ser40, Ser13, and Tyr 96 or by succination at Cys93 [60] or by alkylation at Cys107 [61] (Figure 4B)

This pathway mainly regulates ferroptosis by inducing and activating the expression of SREBP1, which can target and activate the downstream SCD1, and SCD1 can inhibit cell ferroptosis by increasing the content of MUFA